"Antiplasmodial Activity of ArtemetherLumefantrine-Tinidazole on Plasmo" by Owunari Georgewill Udeme, Melford Harold et al.

Article Title

Antiplasmodial Activity of ArtemetherLumefantrine-Tinidazole on Plasmodium Berghei Infected Mice

Erratum

ARTICLE WITHDRAWN due to no response to queries from the journal/publisher or duplicate publication elsewhere.

Authors

Owunari Georgewill Udeme, Department of Pharmacology, Faculty of Clinical Sciences, University of Port Harcourt, Rivers State, Nigeria
Melford Harold, ͣDepartment of Pharmacology, Faculty of Clinical Sciences, University of Port Harcourt, Rivers State, Nigeria
Adikwu Elias, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Bayelsa State, Nigeria

Abstract

Introducion: The impact of malaria scourge has been characterized by daunting challenges including antimalarial drug resistance. This necessitates the search for newer antimalaria drugs using approaches including drug repurposing. This study assessed whether Tinidazole (T) can be repurposed as antimalaria in combination with artemether/lumefantrine (A/L) in Plasmodium berghei infected mice. Materials and Methods: Plasmodium berghei infected mice were grouped and orally treated with A/L (2.3/13.7mg/kg), T (28.6 mg/kg), and A/L/T daily in curative, suppressive and prophylactic studies. The negative control (NC) and positive control (MC) were orally treated with 0.9% normal saline (0.2mL) and chloroquine (CQ) (10mg/kg) daily for 4 days, respectively. After drug administration, blood samples were collected and evaluated for parasitemia level, lipid and hematological parameters. Results: Significant decreases in parasitemia levels in the curative, suppressive and prophylactic groups were observed in mice treated with T (28.6 mg/kg) (p

Recommended Citation

Udeme, Owunari Georgewill; Harold, Melford; and Elias, Adikwu (2020) "Antiplasmodial Activity of ArtemetherLumefantrine-Tinidazole on Plasmodium Berghei Infected Mice," Health Sciences: Vol. 1: Iss. 1, Article 32.
Available at: https://doi.org/10.15342/hs.2020.246

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